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Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking zopiclone, it is especially important that your doctor and pharmacist know if you are taking any of the following: But if you still wan't to try it I would absolutely stay under 50 mg and past 15-20 mg it is unlikely anything more will happen, things start to plateau. At 15-20 mg the risks of side effects are also very low. Going over 20 mg and especially over 50 mg is where significant side effects are going to start to happen, not death but things you don't want. Patients with kidney disease: Treatment should be started with a dose of 3.75mg. Children: not recommended. When you’re presenting an argument, it’s important to back up what you’re saying. You need to have relevant facts and examples at your fingertips and think ahead to what your opponents might say. It’s also helpful to know how to talk in broad terms and give your argument some contrast. Finally, it’s good to know how to conclude your argument in a clear, concise way.